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Published Research and Relevant Literature by Dr. Littrup

Click the links for published articles in PDF format, including short summaries.


Renal Ablation (Kidney)

  1. *Littrup P, Ahmed A, Aoun, H, Noujaim D, Harb T, Nakat S, Abdallah K, Adam B, Sakr W, Edson P, Heilbrun L. CT-guided percutaneous cryotherapy of renal masses. J Vasc Interv Radiology 2007; 18:383-92.

PDF Summary: Original renal cryoablation article which first defines the “1-2 rule” for achieving optimal cryoablation technique, resulting in low complication and recurrence rates.

  1. Kam AW, Littrup PJ, Walther MM, Hvizda J, Wood BJ. Thermal protection during percutaneous thermal ablation of renal cell carcinoma. J Vasc Interv Radiol 2004; 15:753-8.
  2. Georgiades CS, Rodriguez R, Littrup PJ, Frangakis CE, Leveille R, Ahrar K, Atwell TD, Cadeddu J, Trimmer C, Durack JC, Hammers HJ, Meng MV, Raman S, Solomon SB, Zagoria RJ, McLennan G, Laberge JM, Gervais DA, Kee ST. Development of a research agenda for percutaneous renal tumor ablation: proceedings from a multidisciplinary research consensus panel. J Vasc Interv Radiol 2010; 21:1807-16.


Hepatic Ablation (Liver)

  1. Woldie I, Littrup P, Aoun H, Bankuru S, Andersen J, Schiffer C. Retrospective review of thrombocytopenia and coagulopathy following hepatic cryoablation. Haemophilia 2014; 19:464-464.
  2. 2.     *Littrup PJ, Aoun HD, Adam B, Krycia M, Prus M, Shields A. Percutaneous cryoablation of hepatic tumors: long-term experience of a large U.S. series. Abdom Radiol 2016; 41:767-80. PMID: 26960728.

PDF Summary: Recent summary hepatic cryoablation article describing are long-term experience from both a historical perspective of lessons learned, as well as moderate and safety parameters for avoiding “cryo shock phenomenon” by limiting tumor ablation size to <4 cm in patients with >100,000 platelets.


Thoracic Ablation (Lung or Chest Wall)

  1. *Wang H, Littrup PJ, Duan Y, Zhang Y, Feng H, Nie Z. Thoracic masses treated with percutaneous cryotherapy: initial experience with more than 200 procedures. Radiology. 2005; 235:289-98.

PDF Summary: Pioneering article done in collaboration with our Chinese collaborators that set the tone for more thorough extensive ablations in the US.

  1. Ahmed A, Littrup P. Percutaneous cryoablation of the thorax: safety considerations for complex cases. AJR Am J Roentgentol 2006; 186:1703-6.
  2. Hinshaw JL, Littrup PJ, Durick N, Leung W, Lee FT Jr, Sampson L, Brace CL. Optimizing the protocol for pulmonary cryoablation: a comparison of a dual- and triple-freeze protocol. Cardiovasc Intervent Radiol 2010; 33:1180-5.
  3. Ahrar K and Littrup PJ. Is cryotherapy the optimal technology for ablation of lung tumors?  J Vasc Interv Radiol 2012; 23:303-5.
  4. de Baere T, Tselikas L, Woodrum D, Abtin F, Littrup P, Deschamps F, Suh R, Aoun HD, Callstrom M. Evaluating Cryoablation of Metastatic Lung Tumors in Patients–Safety and Efficacy: The ECLIPSE Trial–Interim Analysis at 1 Year. J Thorac Oncol. 2015; 10(10):1468-74. doi: 10.1097/JTO.0000000000000632. PMID: 26230972
  5. de Baere T, Tselikas L, Woodrum D, Abtin F, Littrup P, Deschamps F, Suh R, Aoun HD, Callstrom M. Evaluating Cryoablation of Metastatic Lung Tumors in Patients – Safety and Efficacy: The ECLIPSE trial – Interim analysis at 1-Year. Cardiol Rev. 2015 Jul 29. [Epub ahead of print]. PMID: 26258688


Soft Tissue Ablation (ST = non-organ)

  1. Solomon LA, Munkarah AR, Vorugu VR, Deppe G, Adam B, Malone JM Jr, Littrup PJ. Image-guided percutaneous cryotherapy for the management of gynecologic cancer metastases. Gynecol Oncol. 2008; 111:202-7.
  2. Bang HJ, Littrup PJ, Goodrich DJ, Currier BP, Aoun HD, Heilbrun LK, Vaishampayan U, Adam B, Goodman AC. Percutaneous cryoablation of metastatic renal cell carcinoma for local tumor control: feasibility, outcomes, and estimated cost-effectiveness for palliation. J Vasc Interv Radiol. 2012; 23:770-7.
  3. Bang HJ, Littrup PJ, Currier BP, Goodrich DJ, Aoun HD, Klein LC, Kuo JC, Heilbrun LK, Gadgeel S, Goodman AC. Percutaneous cryoablation of metastatic lesions from non-small-cell lung carcinoma: Initial survival, local control, and cost observations. J Vasc Interv Radiol. 2012; 23:761-9.
  4. Bang HJ, Littrup PJ, Currier BP Goodrich DJ, Choi M, Heilbrun LK, Goodman AC. Percutaneous cryoablation of metastatic lesions from colorectal cancer: Efficacy and feasibility with survival and cost-effectiveness observations. ISRN Minimally Invasive Surgery. Volume 2012, Article ID 942364, 10 pages.
  5. Callstrom MR, Dupuy DE, Solomon SB, Beres RA, Littrup PJ, Davis KW, Paz-Fumagalli R, Hoffman C, Atwell TD, Charboneau JW, Schmit GD, Goetz MP, Rubin J, Brown KJ, Novotny PJ, Sloan JA. Percutaneous image-guided cryoablation of painful metastases involving bone: Multicenter trial. Cancer 2013; 119:1033-41.
  6. *Littrup PJ, Bang HJ, Currier B, Goodrich D, Aoun HD, Heilbrun L, Adam B. Soft tissue cryoablation in diffuse locations: Feasibility and intermediate outcomes. J Vasc Interv Radiol. 2013; 24:1817-25.

PDF Summary: Recent summary ST cryoablation article describing our long-term experience for nearly any metastatic tumor type and location with excellent local control rates, as well as cost efficacy noted for specific diseases by Bang et al. above.


Breast Ablation

  1. Kaufman CS, Littrup PJ, Freman-Gibb LA, Francescatti D, Stocks LH, Smith JS, Henry CA, Bailey L, Harness JK, Simmons R. Office-based ultrasound-guided cryoablation of breast fibroadenomas. Am J Surg. 2002; 184: 394-400.
  2. Kaufman CS, Bachman B, Littrup PJ, Freeman-Gibb LA, White M, Carolin K, Francesatti D, Stocks LH, Smith JS, Henry CA, Bailey L, Harness JK, Simmons R. Cryoablation treatment of benign breast lesions with 12-month follow-up. AM J Surg. 2004; 188: 340-8.
  3. Kaufman CS, Littrup PJ, Freeman-Gibb LA, Smith JS, Francescatti D, Simmons R, Stocks LH, Baily L, Harness JK, Bachman BA, Henry CA. Office-based cryoablation of breast fibroadenomas with long-term follow-up. Breast J 2005; 11:344-50
  4. *Littrup PJ, Freeman-Gibb L, Andea A, White M, Amerikia KC, Bouwman D, Harb T, Sakr W. Cryotherapy for breast fibroadenomas. Radiology 2005; 234: 63-72.
  5. PDF Summary: Original fibroadenoma cryoablation article defining optimal technique for maximum effect while minimizing collateral damage to adjacent normal breast tissue.
  6. *Littrup PJ, Jallad B, Chandiwala-Mody P, D’Agostini M, Adam BA, Bouwman D. Cryotherapy for breast cancer: a feasibility study without excision.  J Vasc Interv Radiol 2009; 20:1329-41.

PDF Summary: Original breast cancer cryoablation article defining optimal technique for maximum control while minimizing complication risk.


Renal Ablation Hepatic Ablation Thoracic Ablation Soft Tissue Ablation Breast Ablation